Single-cell multiplex chromatin and RNA interactions in aging human brain
Authors: Xingzhao Wen, Zhifei Luo, Wenxin Zhao, Riccardo Calandrelli, Tri C. Nguyen, Xueyi Wan, John Lalith Charles Richard, Sheng Zhong
Journal: Nature, 2024
The study investigates chromatin and RNA interactions at the single-cell level in the aging human brain to uncover cellular and sex-specific differences contributing to brain aging and neurodegenerative diseases.
MUSIC (Multiplexed Indexed Sequential Chromatin Conformation) technology was used to jointly profile gene expression, chromatin interactions, and RNA-chromatin associations in single cells.
This study enhances our understanding of brain aging mechanisms, emphasizing cell-type and sex-specific differences, with implications for targeted therapies for neurodegenerative diseases.